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The benefit is in tolerability and consistency, not in enhanced efficacy

However, this would not likely be a limiting issue in astrocytes, as PCK1 was shown to be expressed at very low levels in the brain, mostly in neurons, but could be expressed in astrocytes following brain injury (Geng et al., 2021)

Diabetologia 2010, 53, 22562263

Clinical data suggests the drug supports meaningful weight loss and can be taken without strict food or timing requirements, potentially improving ease of use and adherence

Its novel mechanism of action has led to growing clinical interest, particularly in managing sexual dysfunction where traditional vasodilator agents (e.g., PDE5 inhibitors) have been insufficient or contraindicated

62 , e1700770 (2018)